Investigating of variations in BRCA1 gene in Iranian families with breast cancer
نویسندگان
چکیده
منابع مشابه
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولBRCA1 Mutations in Northeastern Iranian Breast Cancer Families
Breast cancer (BC) is the most common malignancy in women and the leading cause of cancer death in females worldwide, accounting for 23% (1.38 million) of total new cancer cases and 14% (458,400) of the total cancer deaths in 2008. In the USA, the estimated number of new cases of BC in 2012 was 226,870, of which 39,510 resulted in death (American Cancer Society, 2012). The incidence rates of br...
متن کاملsequence variants of brca1 and brca2 genes in four iranian families with breast and ovarian cancer
background: brca1 and brca2 genes have been recognized to be responsible for 20-30% of hereditary breast cancers and approximately 50% of familial breast and ovarian cancers. therefore, the demand for brca1 and brca2 mutation screening is rapidly increasing as their identification will affect medical management of people at increased risk. because of high costs involved in analysis of brca1 a...
متن کاملAnalysis of novel mutations in BRCA1 in Iranian families with breast cancer.
In Iran and the rest of the world, breast cancer (BC) is the most common malignancy in women. Familial history and age are significant risk factors for the development of this disease in Iran. Most hereditary BCs are associated with inherited mutations in the BRCA1 and BRCA2 genes. Some recent studies demonstrated that BRCA1 mutations are seen in high-risk women with family histories of BC. In ...
متن کاملSequence Variants of BRCA1 and BRCA2 Genes in Four Iranian Families with Breast and Ovarian Cancer
BACKGROUND BRCA1 and BRCA2 genes have been recognized to be responsible for 20-30% of hereditary breast cancers and approximately 50% of familial breast and ovarian cancers. Therefore, the demand for BRCA1 and BRCA2 mutation screening is rapidly increasing as their identification will affect medical management of people at increased risk. Because of high costs involved in analysis of BRCA1 and ...
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ژورنال
عنوان ژورنال: Medical Journal of the Islamic Republic of Iran
سال: 2018
ISSN: 1016-1430,2251-6840
DOI: 10.14196/mjiri.32.87